Karachi, April 22, 2022 (PPI-OT): KSE-100 lost 291 points yesterday, to close at 45,653 with 186Mn shares being traded. Top performance as per price change was witnessed in LOTCHEM, AKBL and CNERGY. Top decliners SCBPL, ISL and UNITY. Activity was mainly concentrated In Chemical, Refinery and Technology.